Uzbekistan Airways fly to and from Moscow Domodedovo (DME) Airport on Mondays using an A-320. A high-speed Aeroexpress train travels to and from Paveletsky-Moscow to Domodedovo Airport. Journey time: 40-50 minutes.
The Gazpromavia company of Russia has three flights a week connecting Moscow and Nukus, the capital of Karakalpakstan. From Moscow Vnukovo (VKO) airport using the new Yak-42. A fast airexpress train goes from Moscow's Kievsky railway station to Vnukovo Airport. Journey time: 35 minutes.
The cost of taking both airlines similar (see agent).
NOTE: Alongside Nukus Airport another good entry point for western Uzbekistan is Urgench Airport (UGC) located 119 Km away.(Note: Ural Airlines and Uzbekistan Airlines also serve on the Urgench - Moscow route)